Description

(S)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the design and optimization of lead compounds, especially in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Precursor for Biologically Active Molecules: Utilized in the preparation of compounds with potential enzyme inhibitory or receptor binding activity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	(S)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile
CAS No.	1213890-35-7
Molecular Formula	C9H8F2N2O
Molecular Weight	198.17 g/mol
Synonyms	(S)-2-Amino-1-(3-cyano-2,4-difluorophenyl)ethanol; (S)-1-(3-Cyano-2,4-difluorophenyl)-2-aminoethanol; (S)-4-(1-Amino-2-hydroxyethyl)-2,6-difluorobenzonitrile; 2,6-Difluoro-4-[(1S)-1-amino-2-hydroxyethyl]benzonitrile; Benzonitrile, 4-[(1S)-1-amino-2-hydroxyethyl]-2,6-difluoro-; (S)-enantiomer of 4-(1-Amino-2-hydroxyethyl)-2,6-difluorobenzonitrile
EINECS	Contact for details

Quality Control

Our (S)-4-(1-Amino-2-Hydroxyethyl)-2,6-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.