Description

(R)-2,2,2-Trifluoro-1-(2-Fluorophenyl)Ethan-1-Amine is a high-value, chiral fluorinated amine building block essential for modern synthetic chemistry. Its core value lies in providing a stereochemically defined, fluorine-containing scaffold that can dramatically influence the biological activity and metabolic stability of target molecules. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in the creation of enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the design of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or additive for specialty polymers and advanced materials where fluorine content can alter surface properties and chemical resistance.
• Fluorine Chemistry & SAR Studies: An indispensable tool for structure-activity relationship (SAR) studies to understand the impact of trifluoromethyl and fluorine substituents on molecular properties.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(2-Fluorophenyl)Ethan-1-Amine
CAS No.	1213579-16-8
Molecular Formula	C8H7F4N
Molecular Weight	193.14 g/mol
Synonyms	(R)-1-(2-Fluorophenyl)-2,2,2-trifluoroethanamine; (R)-α-(Trifluoromethyl)-2-fluorobenzylamine; (R)-2,2,2-Trifluoro-1-(2-fluorophenyl)ethylamine; (R)-1-(2-Fluorophenyl)-2,2,2-trifluoroethylamine; (R)-2-Fluoro-α-(trifluoromethyl)benzylamine; (R)-F-Phenyl-CF3-ethylamine; (R)-F-TFMA; (R)-Enantiomer of 2,2,2-Trifluoro-1-(2-fluorophenyl)ethanamine
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(2-Fluorophenyl)Ethan-1-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee >99%) and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.