Description

3-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is a high-value, chiral trifluoromethylated building block essential for modern pharmaceutical and agrochemical research. Its unique structure, featuring a benzonitrile moiety and a chiral amino-trifluoroethyl group, makes it a critical intermediate for synthesizing bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical industry for the creation of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorine-containing motifs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in CNS, oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the incorporation and behavior of fluorine atoms in organic molecules.

Basic Information

Product Name	3-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile
CAS No.	1213470-65-5
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	(S)-3-(1-Amino-2,2,2-trifluoroethyl)benzonitrile; (1S)-1-Amino-2,2,2-trifluoro-1-(3-cyanophenyl)ethane; 3-[(1S)-1-Amino-2,2,2-trifluoroethyl]benzonitrile; Benzonitrile, 3-((1S)-1-amino-2,2,2-trifluoroethyl)-; (S)-α-(Aminomethyl)-3-cyanobenzyltrifluoride
EINECS	Contact for details

Quality Control

Our 3-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying purity, chiral excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.