Description

(1S)-1-(2,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is a high-value chiral amine building block characterized by its trifluoroethyl and dimethylphenyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its specific stereochemistry and fluorine content are essential for biological activity and metabolic stability. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced efficacy and environmental persistence.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Material Science Research: Intermediate for synthesizing specialty monomers or additives for advanced polymers and fluorinated materials.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or molecular probes used in biochemical and pharmacological research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific chiral scaffold.

Basic Information

Product Name	(1S)-1-(2,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1213180-49-4
Molecular Formula	C10H12F3N
Molecular Weight	203.20 g/mol
Synonyms	(S)-1-(2,4-Dimethylphenyl)-2,2,2-trifluoroethanamine; (1S)-1-(2,4-Dimethylphenyl)-2,2,2-trifluoroethanamine; (S)-α-Methyl-2,4-dimethylbenzylamine trifluoro derivative; (S)-2,4-Dimethyl-α-(trifluoromethyl)benzylamine; (S)-1-(2,4-Dimethylphenyl)-2,2,2-trifluoroethylamine; (S)-TFM-DMPA; (S)-Trifluoroethyl-2,4-dimethylbenzylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-(2,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.