Description

Benzonitrile, 3-[(1R)-1-Aminoethyl]-4-Fluoro- CAS NO 1212934-10-5 is a high-purity, chiral fluorinated benzonitrile derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its unique molecular architecture, combining a chiral aminoethyl side chain with a fluorine substituent, which is essential for modulating the biological activity and metabolic stability of target drug molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom enhances bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and receptor interactions.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers with specific optical or electronic properties.

Basic Information

Product Name	Benzonitrile, 3-[(1R)-1-Aminoethyl]-4-Fluoro-
CAS No.	1212934-10-5
Molecular Formula	C9H9FN2
Molecular Weight	164.18 g/mol
Synonyms	(R)-3-(1-Aminoethyl)-4-fluorobenzonitrile; 4-Fluoro-3-[(1R)-1-aminoethyl]benzonitrile; 3-[(1R)-1-Aminoethyl]-4-fluorobenzonitrile; (R)-4-Fluoro-3-(1-aminoethyl)benzonitrile; 1212934-10-5; 4-Fluoro-3-[(R)-1-aminoethyl]benzonitrile; Benzonitrile, 4-fluoro-3-[(1R)-1-aminoethyl]-; (1R)-1-(4-Cyano-2-fluorophenyl)ethanamine
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 3-[(1R)-1-Aminoethyl]-4-Fluoro- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) documenting identity, purity (assay), chiral purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.