Description

4-((1R)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is a high-value chiral building block featuring a benzonitrile core substituted with a trifluoroethylamine group. This compound is critical for introducing the trifluoroethyl pharmacophore and chiral amine functionality into advanced molecular architectures. It is primarily utilized by pharmaceutical and agrochemical R&D organizations for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small molecule drugs, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry Studies: A valuable substrate for investigating structure-activity relationships (SAR) and metabolic pathways influenced by fluorine substitution.

Basic Information

Product Name	4-((1R)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile
CAS No.	1212926-88-9
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	(R)-4-(1-Amino-2,2,2-trifluoroethyl)benzonitrile; (1R)-1-(4-Cyanophenyl)-2,2,2-trifluoroethanamine; (R)-α-(Aminomethyl)-4-cyanobenzyltrifluoride; 4-[(1R)-1-Amino-2,2,2-trifluoroethyl]benzonitrile; (R)-1-(4-Cyanophenyl)-2,2,2-trifluoroethylamine; p-((R)-1-Amino-2,2,2-trifluoroethyl)benzonitrile; (R)-4-(Aminomethyl)-α,α,α-trifluoro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-((1R)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.