Description

4-Fluoro-3-Nitrophenylacetylene is a high-purity, multi-functional aromatic acetylene building block. This compound is valued for its unique molecular architecture, which combines an electron-withdrawing nitro group and a fluorine substituent with a reactive terminal alkyne, enabling precise synthetic transformations. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions, click chemistry, and the synthesis of complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs) and bioactive molecules via Sonogashira, Glaser, or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fluorine and nitro groups for bioactivity modulation.
• Material Science: Serves as a monomer or cross-linker in the synthesis of conjugated polymers, organic semiconductors, and metal-organic frameworks (MOFs) for electronic and optoelectronic devices.
• Click Chemistry Reagent: The terminal alkyne group makes it an ideal participant in Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) for bioconjugation and polymer functionalization.
• Ligand Synthesis: Used to prepare specialized ligands for catalysis, where the acetylene group can be functionalized to create complex chelating structures.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags, photoaffinity labels, and other molecular probes for studying biological systems.

Basic Information

Product Name	4-Fluoro-3-Nitrophenylacetylene
CAS No.	1211528-74-3
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	1-Ethynyl-4-fluoro-3-nitrobenzene; 4-Fluoro-3-nitrobenzeneacetylene; 3-Nitro-4-fluorophenylacetylene; (4-Fluoro-3-nitrophenyl)ethyne; 1-Fluoro-2-nitro-4-ethynylbenzene; 4-Fluoro-3-nitroethynylbenzene; 4-Fluoro-3-nitrophenyl acetylene
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Nitrophenylacetylene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.