Description

5-Bromo-2-(trifluoromethyl)benzonitrile is a high-purity, multi-functional aromatic nitrile building block, distinguished by its bromine and trifluoromethyl substituents. This compound is engineered to provide reliable performance and consistent quality for advanced chemical synthesis, where precise molecular architecture is critical. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the halogen and fluorine groups.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational component in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Research: An important reagent for studying the effects of trifluoromethyl groups on the physicochemical properties and metabolic stability of organic compounds.
• Polymer & Resin Modifier: Employed to introduce bromine and cyano functionalities into polymer chains, enhancing flame retardancy and thermal stability.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)benzonitrile
CAS No.	1208076-28-1
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)benzonitrile; 5-Bromo-α,α,α-trifluoro-o-tolunitrile; 2-Cyano-4-bromobenzotrifluoride; 4-Bromo-2-(trifluoromethyl)benzonitrile; Benzonitrile, 5-bromo-2-(trifluoromethyl)-; 1208076-28-1; 5-Bromo-2-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.