Description

6-Bromo-2,3-Difluorobenzonitrile is a high-purity, multi-functional aromatic building block characterized by its bromine, fluorine, and nitrile substituents. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering precise reactivity for constructing sophisticated chemical architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs, due to its electron-withdrawing nitrile group and halogenated structure.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, where the bromine atom acts as a handle for carbon-carbon and carbon-heteroatom bond formation.
• Fluorinated Compound Libraries: Integral for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	6-Bromo-2,3-Difluorobenzonitrile
CAS No.	1207875-87-3
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2,3-Difluoro-6-bromobenzonitrile; 6-Bromo-2,3-difluorobenzene carbonitrile; 2-Bromo-4,5-difluorobenzonitrile; Benzonitrile, 6-bromo-2,3-difluoro-; 1-Bromo-2,3-difluoro-4-cyanobenzene
EINECS	Contact for details

Quality Control

Our 6-Bromo-2,3-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.