Description

1-(Difluoromethoxy)-2-Methoxy-4-Nitrobenzene is a specialized fluorinated aromatic compound that serves as a valuable synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both difluoromethoxy and nitro substituents, makes it a critical building block for constructing complex molecules with tailored electronic and physical properties. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the nitro and difluoromethoxy groups contribute to biological activity.
• Material Science: Building block for advanced organic materials, including liquid crystals, polymers, and organic electronic components.
• Chemical Synthesis: Versatile reagent for introducing the 1-(difluoromethoxy)-2-methoxy-4-nitrobenzene moiety into more complex molecular architectures via coupling or substitution reactions.
• Dye & Pigment Intermediates: Potential intermediate in the synthesis of specialized nitro-aromatic dyes and colorants.

Basic Information

Item	Details
Product Name	1-(Difluoromethoxy)-2-Methoxy-4-Nitrobenzene
CAS No.	1198109-79-3
Molecular Formula	C8H7F2NO4
Molecular Weight	219.14 g/mol
Synonyms	2-Methoxy-4-nitro-1-(difluoromethoxy)benzene; 4-Nitro-2-methoxy-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-2-methoxy-4-nitro-benzene; Benzene, 1-(difluoromethoxy)-2-methoxy-4-nitro-; DFM-Methoxy-Nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-2-Methoxy-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.