Description

Endoxifen (E-Isomer Hydrochloride) is a selective estrogen receptor modulator (SERM) and a major active metabolite of tamoxifen. This high-purity compound is critical for pharmaceutical research and development, particularly in the study of breast cancer therapeutics and endocrine-related pathways. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery, preclinical studies, and analytical reference standard preparation.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for quality control and analytical method development in drug manufacturing.
• Oncology Research: Used in preclinical studies to investigate its efficacy, mechanism of action, and pharmacokinetics as a potential breast cancer therapeutic.
• Biochemical Assay Development: Employed as a key reagent in cell-based and in vitro assays targeting estrogen receptor activity.
• Metabolite Studies: Essential for comparative pharmacological studies against tamoxifen and other metabolites.
• Formulation Development: Used in early-stage development of novel drug formulations and delivery systems.
• Academic Research: A vital tool for universities and research labs studying endocrine signaling and cancer biology.

Basic Information

Product Name	Endoxifen (E-Isomer Hydrochloride)
CAS No.	1197194-61-8
Molecular Formula	C26H29NO2 • HCl
Molecular Weight	415.98 g/mol (as hydrochloride salt)
Synonyms	Z-Endoxifen Hydrochloride; (E)-N-Desmethyl-4-hydroxytamoxifen Hydrochloride; (Z)-4-Hydroxy-N-desmethyltamoxifen Hydrochloride; ENDX HCl; Major Tamoxifen Metabolite Hydrochloride; FC-1271a Hydrochloride; (E)-Endoxifen HCl
EINECS	Contact for details

Quality Control

Our Endoxifen (E-Isomer Hydrochloride) is manufactured under strict quality systems suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications, test methods, and results—including chiral purity to confirm the E-isomer—is provided with every shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (E-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.