Description

Endoxifen (Hydrochloride) CAS NO 1197194-41-4 is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) and the primary active metabolite of tamoxifen. It is a critical compound for advanced pharmaceutical research and development, particularly in the field of oncology. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel breast cancer therapeutics and studying endocrine-responsive pathways.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as a key intermediate or final active ingredient in the formulation of novel breast cancer treatments.
• Oncology Research: Used in preclinical and clinical studies to investigate its efficacy and mechanisms of action against estrogen receptor-positive (ER+) cancers.
• Metabolite Standard: Employed as a certified reference standard in bioanalytical laboratories for the quantification of tamoxifen and its metabolites in pharmacokinetic studies.
• Biochemical Research: Utilized in vitro to study estrogen receptor binding, modulation, and downstream signaling pathways.
• Drug Development: Integral to formulation development, stability testing, and the creation of new dosage forms for improved therapeutic profiles.

Basic Information

Product Name	Endoxifen (Hydrochloride)
CAS No.	1197194-41-4
Molecular Formula	C26H30N2O • HCl
Molecular Weight	422.99 g/mol (Free base: 386.53 g/mol)
Synonyms	Z-Endoxifen Hydrochloride; (Z)-4-Hydroxy-N-desmethyltamoxifen Hydrochloride; N-Desmethyl-4-hydroxytamoxifen Hydrochloride; ENDX HCl; FC-1271a Hydrochloride; Afimoxifene Hydrochloride; Major Tamoxifen Metabolite Hydrochloride
EINECS	Contact for details

Quality Control

Our Endoxifen Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the Z-isomer configuration, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and compliance with in-house specifications developed for research and pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isomeric Purity (Z-Isomer)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.