Description

3-(Trifluoromethyl)Morpholine is a high-value fluorinated heterocyclic building block, essential for introducing the trifluoromethyl-morpholine moiety into advanced molecular architectures. Its primary value lies in enabling the fine-tuning of physicochemical properties such as lipophilicity, metabolic stability, and bioavailability in target compounds. This specialty intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its unique electronic properties.
• Chemical Biology & Medicinal Chemistry: A valuable probe and building block for structure-activity relationship (SAR) studies and library synthesis.
• Catalyst & Ligand Development: Potential component in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3-(Trifluoromethyl)Morpholine
CAS No.	1196152-13-2
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	3-(Trifluoromethyl)morpholine; Morpholine, 3-(trifluoromethyl)-; 3-Trifluoromethylmorpholine; 2,2,2-Trifluoro-1-morpholin-4-ylethanone (tautomer); 4-(Trifluoroacetyl)morpholine (tautomer); TFMM; 3-TFM
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.