Description

(Z)-3-Chloro-3-(3-Fluorophenyl)Acrylonitrile CAS NO 1192875-03-8 is a high-value, halogenated acrylonitrile derivative characterized by its distinct stereochemistry and functional groups. This compound serves as a critical advanced pharmaceutical intermediate and versatile organic synthesis building block for constructing complex molecular architectures. It is primarily sought after by research institutions and chemical manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, or insecticides, leveraging the bioactivity of the fluorophenyl and nitrile groups.
• Material Science Research: Monomer or cross-linking agent in the research and development of specialty polymers, liquid crystals, or advanced organic electronic materials.
• Organic Synthesis Reagent: Used in Michael addition reactions, cyclization processes, and as a dienophile in Diels-Alder reactions to create complex heterocyclic compounds.
• Chemical Biology Probe: Serves as a tool compound for studying enzyme inhibition or protein labeling due to its electrophilic β-carbon and specific stereochemistry.

Basic Information

Product Name	(Z)-3-Chloro-3-(3-Fluorophenyl)Acrylonitrile
CAS No.	1192875-03-8
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	(Z)-3-Chloro-3-(3-fluorophenyl)prop-2-enenitrile; 3-Chloro-3-(3-fluorophenyl)acrylonitrile (Z-isomer); (Z)-3-Chloro-3-(m-fluorophenyl)acrylonitrile; (Z)-β-Chloro-β-(3-fluorophenyl)acrylonitrile; (Z)-2-Propenenitrile, 3-chloro-3-(3-fluorophenyl)-; (Z)-3-(3-Fluorophenyl)-3-chloroacrylonitrile; (Z)-3-Chloro-3-(3-fluorobenzene)acrylonitrile
EINECS	Contact for details

Quality Control

Our production of (Z)-3-Chloro-3-(3-Fluorophenyl)Acrylonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity (Z-Isomer)	≥ 99.0% (by HPLC or NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.