Description

5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise and reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine and nitrile groups impart desirable biological activity and metabolic stability.
• Material Science & OLED Development: Serves as a precursor for creating complex organic semiconductors, liquid crystals, and light-emitting materials for electronic displays and devices.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities via palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Preparation: Utilized in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced catalytic processes.

Basic Information

Product Name	5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1192023-08-7
Molecular Formula	C14H17BFNO2
Molecular Weight	261.10 g/mol
Synonyms	4-Cyano-3-fluoro-6-methylphenylboronic acid pinacol ester; (4-Cyano-3-fluoro-6-methylphenyl)boronic acid pinacol ester; 2-Fluoro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 5-Fluoro-2-methyl-4-(pinacolatoboron)benzonitrile; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-2-methylbenzonitrile; PINACOL (4-CYANO-3-FLUORO-6-METHYLPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.