Description

1,5-Difluoro-2-Methyl-3-Nitro-Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring both electron-withdrawing nitro and fluorine groups adjacent to a methyl group, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoromethylbenzene or nitrophenyl core structure.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Dye & Pigment Industry: Acts as an intermediate in the manufacture of complex organic dyes and pigments, leveraging its nitro group for further functionalization.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create biaryl structures common in many functional compounds.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on aromatic systems and reaction pathways in academic and industrial R&D settings.

Basic Information

Product Name	1,5-Difluoro-2-Methyl-3-Nitro-Benzene
CAS No.	1188412-98-7
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Methyl-3,5-difluoronitrobenzene; 3,5-Difluoro-2-methylnitrobenzene; 1,5-Difluoro-2-methyl-3-nitrobenzene; 3-Nitro-2,6-difluorotoluene; 2,6-Difluoro-3-nitrotoluene; Benzene, 1,5-difluoro-2-methyl-3-nitro-; 1188412-98-7
EINECS	Contact for details

Quality Control

Our 1,5-Difluoro-2-Methyl-3-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon to maintain optimal purity and stability. Keep away from strong oxidizing agents, strong bases, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.