Description

4-Bromo-2-(trifluoromethoxy)benzonitrile is a high-value, multi-functional aromatic intermediate featuring both bromo and trifluoromethoxy substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for constructing complex heterocycles and active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a precursor in the manufacture of advanced electronic materials for displays and lighting, leveraging its rigid, halogenated structure.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of the trifluoromethoxy group on physicochemical properties like lipophilicity and bioavailability in medicinal chemistry.
• Polymer Modification: Employed to introduce functional aromatic units into polymer backbones to alter thermal stability, refractive index, or chemical resistance.

Basic Information

Product Name	4-Bromo-2-(trifluoromethoxy)benzonitrile
CAS No.	1187983-97-6
Molecular Formula	C8H3BrF3NO
Molecular Weight	266.02 g/mol
Synonyms	4-Bromo-2-(trifluoromethoxy)benzonitrile; 2-Trifluoromethoxy-4-bromobenzonitrile; 4-Bromo-α,α,α-trifluoro-o-anisonitrile; Benzonitrile, 4-bromo-2-(trifluoromethoxy)-; 4-Bromo-2-trifluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(trifluoromethoxy)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material integrity for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.