Description

5-Chloro-2-Fluoro-Benzamidine Hydrochloride is a high-purity, functionalized benzamidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in providing a reactive amidine group ortho-substituted with halogen atoms, enabling precise molecular construction for advanced applications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides requiring specific halogenated benzamidine motifs.
• Chemical Biology & Proteomics: Serves as a precursor for affinity chromatography ligands or activity-based probes targeting serine proteases.
• Material Science Research: Employed in the synthesis of specialized polymers, ligands for metal-organic frameworks (MOFs), or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Chloro-2-Fluoro-Benzamidine Hydrochloride
CAS No.	1187929-52-7
Molecular Formula	C7H7ClFN2•HCl
Molecular Weight	209.05 g/mol (Free base: 172.60)
Synonyms	5-Chloro-2-fluorobenzamidine hydrochloride; 2-Fluoro-5-chlorobenzamidine HCl; Benzenecarboximidamide, 5-chloro-2-fluoro-, hydrochloride (1:1); (5-Chloro-2-fluorophenyl)methanimidamide hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.