Description

4-(Aminomethyl)-2-Fluorobenzonitrile Hydrochloride is a high-purity, fluorinated aromatic nitrile building block with a protected amine functionality. This compound is a critical intermediate in modern pharmaceutical and agrochemical research, enabling the synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, CNS agents, and anti-cancer compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom and nitrile group impart desirable properties.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics & Bio-conjugation: The aminomethyl group facilitates the creation of peptide analogs and is used for bio-conjugation strategies in probe and drug delivery system development.
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials due to its aromatic and polar functional groups.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags, affinity labels, and other molecular probes for diagnostic and research applications.

Basic Information

Product Name	4-(Aminomethyl)-2-Fluorobenzonitrile Hydrochloride
CAS No.	1187927-96-3
Molecular Formula	C8H8FN2•HCl
Molecular Weight	186.62 g/mol (Free base: 150.16 g/mol)
Synonyms	2-Fluoro-4-(aminomethyl)benzonitrile hydrochloride; 4-(Aminomethyl)-2-fluorobenzonitrile HCl; Benzonitrile, 4-(aminomethyl)-2-fluoro-, hydrochloride; 2-Fluoro-4-cyanobenzylamine hydrochloride; 4-Cyano-3-fluorobenzylamine hydrochloride; (4-Cyano-3-fluorophenyl)methanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-2-Fluorobenzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.