Description

6-Bromo-Betamethasone 17,21-Dipropionate is a halogenated derivative of the potent corticosteroid betamethasone, specifically modified at the 6-position with a bromine atom and esterified with propionic acid at the 17 and 21 positions. This structural modification is of significant interest for pharmaceutical research and development, particularly in the synthesis of novel anti-inflammatory agents and as a key intermediate for creating more potent or targeted steroid-based therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced steroid chemistry. The compound is supplied with a focus on high purity and consistency to meet the stringent requirements of synthetic and analytical applications.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of novel corticosteroid derivatives with potential enhanced pharmacological profiles.
• Anti-inflammatory Research: Used in preclinical studies to investigate structure-activity relationships (SAR) of halogenated steroids for treating inflammatory and autoimmune conditions.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid APIs.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of advanced betamethasone analogs.
• Biochemical Research: Used as a tool compound to study steroid receptor interactions and metabolic pathways.

Basic Information

Product Name	6-Bromo-Betamethasone 17,21-Dipropionate
CAS No.	1186048-34-9
Molecular Formula	C28H36BrFO7
Molecular Weight	583.49 g/mol
Synonyms	6-Bromo Betamethasone Dipropionate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate 6-bromo derivative; 6-Bromo-9α-fluoro-16β-methylprednisolone 17,21-dipropionate; Betamethasone 17,21-dipropionate, 6-bromo-; 6-Bromo-9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
EINECS	Contact for details

Quality Control

Our 6-Bromo-Betamethasone 17,21-Dipropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the high standards required for research and development purposes. Certificates of Analysis (COA) documenting all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.