Description

3-(2,5-Difluorophenoxy)Pyrrolidine Hydrochloride is a high-purity, fluorinated pyrrolidine derivative used as a critical pharmaceutical intermediate. This compound is essential for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated phenoxy and pyrrolidine motifs.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: Potential use in the development of biochemical probes for studying enzyme or receptor function.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	3-(2,5-Difluorophenoxy)Pyrrolidine Hydrochloride
CAS No.	1185298-02-5
Molecular Formula	C10H12F2NO•HCl
Molecular Weight	235.67 g/mol (Free base: 199.21 g/mol)
Synonyms	3-(2,5-Difluorophenoxy)pyrrolidine HCl; Pyrrolidine, 3-(2,5-difluorophenoxy)-, hydrochloride; 3-(2,5-Difluorophenoxy)pyrrolidine hydrochloride; 3-(2,5-Difluorophenoxy)pyrrolidine monohydrochloride; 1185298-02-5; 3-(2,5-Difluorophenoxy)-1-pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-(2,5-Difluorophenoxy)Pyrrolidine Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.