Description

4-(2,2-Difluoroethoxy)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a difluoroethoxy side chain attached to a benzonitrile core, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and scale-up of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays, leveraging the polarity and conformational rigidity of the difluoroethoxy group.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with unique surface properties, chemical resistance, and low dielectric constants.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research: A valuable building block in medicinal chemistry and material science labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-(2,2-Difluoroethoxy)Benzonitrile
CAS No.	1184375-73-2
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	4-(2,2-Difluoroethoxy)benzonitrile; Benzonitrile, 4-(2,2-difluoroethoxy)-; 2,2-Difluoroethyl 4-cyanophenyl ether; 4-Cyanophenyl 2,2-difluoroethyl ether; p-(2,2-Difluoroethoxy)benzonitrile; 1184375-73-2; DFEOBN
EINECS	Contact for details

Quality Control

Our 4-(2,2-Difluoroethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.