Description

5-(Diethoxymethyl)-2-Fluorobenzonitrile is a specialized fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a protected aldehyde equivalent (diethoxymethyl group) adjacent to both a fluorine atom and a nitrile group, makes it a versatile precursor for constructing complex heterocycles and functionalized aromatic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and electronic materials for specialized applications.
• Chemical Biology Probes: Useful for constructing fluorescent tags or molecular probes due to its reactive nitrile and masked aldehyde functionalities.

Basic Information

Product Name	5-(Diethoxymethyl)-2-Fluorobenzonitrile
CAS No.	1176161-37-7
Molecular Formula	C₁₂H₁₄FNO₂
Molecular Weight	223.24 g/mol
Synonyms	2-Fluoro-5-(diethoxymethyl)benzonitrile; 5-(Diethoxymethyl)-2-fluorobenzonitrile; Benzonitrile, 2-fluoro-5-(diethoxymethyl)-; 2-Fluoro-5-(diethoxymethyl)phenyl cyanide; α,α-Diethoxy-2-fluoro-5-cyanotoluene
EINECS	Contact for details

Quality Control

Every batch of 5-(Diethoxymethyl)-2-Fluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.