Description

Benzene, 2-Fluoro-4-Nitro-1-(Phenoxymethyl)- is a high-purity, fluorinated nitroaromatic compound with a phenoxymethyl substituent, serving as a versatile and critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which enables the precise introduction of fluorine and nitro functional groups into complex target molecules, a key requirement in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials used in displays and organic light-emitting diodes.
• Polymer & Resin Modifier: Employed to introduce specific functional groups into polymer chains, altering properties like solubility, thermal stability, and refractive index for advanced coatings and engineering plastics.
• Dye & Pigment Intermediate: Acts as a building block for synthesizing complex, color-fast nitro- and fluoro- containing dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl and complex heterocyclic systems.

Basic Information

Product Name	Benzene, 2-Fluoro-4-Nitro-1-(Phenoxymethyl)-
CAS No.	1160994-37-5
Molecular Formula	C13H10FNO3
Molecular Weight	247.22 g/mol
Synonyms	1-(Phenoxymethyl)-2-fluoro-4-nitrobenzene; 2-Fluoro-4-nitro-1-(phenoxymethyl)benzene; (2-Fluoro-4-nitrophenyl)methyl phenyl ether; Benzene, 1-(phenoxymethyl)-2-fluoro-4-nitro-; 2-Fluoro-4-nitrobenzyl phenyl ether; α-(2-Fluoro-4-nitrophenyl)anisole; 4-Nitro-2-fluorobenzyl phenyl ether
EINECS	Contact for details

Quality Control

Our Benzene, 2-Fluoro-4-Nitro-1-(Phenoxymethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (argon or nitrogen) in a sealed container. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.