Description

4-Bromo-3-Chloro-2-Fluorobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its multi-substituted aromatic ring structure makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Organic Electronics: Acts as a building block for electron-deficient units in the synthesis of organic semiconductors and non-fullerene acceptors for photovoltaic applications.
• Chemical Biology: Employed as a probe or linker in medicinal chemistry for structure-activity relationship (SAR) studies and bioconjugation.
• Cross-Coupling Reactions: A valuable substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Buchwald-Hartwig amination, enabling diverse molecular architectures.

Basic Information

Product Name	4-Bromo-3-Chloro-2-Fluorobenzonitrile
CAS No.	1160574-68-4
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Fluoro-4-bromo-3-chlorobenzonitrile; 3-Chloro-4-bromo-2-fluorobenzonitrile; Benzonitrile, 4-bromo-3-chloro-2-fluoro-; 4-Bromo-3-chloro-2-fluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.