Description

3-Bromo-5-Chloro-2-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in modern synthetic chemistry. Its unique halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Bromo-5-Chloro-2-Fluorobenzonitrile
CAS No.	1160574-15-1
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Fluoro-3-bromo-5-chlorobenzonitrile; 5-Chloro-3-bromo-2-fluorobenzonitrile; Benzonitrile, 3-bromo-5-chloro-2-fluoro-; 3-Bromo-5-chloro-2-fluorobenzene carbonitrile; 1160574-15-1; 2-Fluoro-3,5-dihalobenzonitrile (mixed halide)
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloro-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards where applicable, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.