Description

3-Bromo-2-Fluoro-5-Iodobenzonitrile is a highly functionalized halogenated benzonitrile derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise and versatile intermediates for coupling reactions and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides due to its halogenated aromatic structure.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions, leveraging the bromo and iodo substituents for sequential functionalization.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for creating tagged molecules and probes for biochemical and diagnostic applications.

Basic Information

Product Name	3-Bromo-2-Fluoro-5-Iodobenzonitrile
CAS No.	1160574-12-8
Molecular Formula	C7H2BrFIN
Molecular Weight	325.90 g/mol
Synonyms	2-Fluoro-3-bromo-5-iodobenzonitrile; 5-Iodo-3-bromo-2-fluorobenzonitrile; Benzonitrile, 3-bromo-2-fluoro-5-iodo-; 3-Bromo-2-fluoro-5-iodobenzene carbonitrile; 1160574-12-8; 3-Br-2-F-5-I-C6H2CN
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-5-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.