Description

2-Ethoxy-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and ethoxy-substituted benzonitrile motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of novel drug candidates, especially in kinase inhibitor and CNS-active compound libraries.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the creation of electron-transport or emissive layers for OLEDs and other electronic devices.
• Chemical Research & Development: A valuable building block for method development in cross-coupling reactions, cyano group transformations, and fluorinated chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific target molecules.

Basic Information

Product Name	2-Ethoxy-5-Fluorobenzonitrile
CAS No.	1158201-03-6
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	5-Fluoro-2-ethoxybenzonitrile; 2-Ethoxy-5-fluorobenzonitrile; Benzonitrile, 2-ethoxy-5-fluoro-; 5-Fluoro-2-ethoxybenzonitrile; 1158201-03-6
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-5-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, from early-stage R&D to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.