Description

3-Fluoro-4-[4-(Hydroxymethyl)Piperidin-1-Yl]Benzonitrile is a high-value, multi-functional chemical building block featuring a benzonitrile core substituted with a fluorinated aryl group and a hydroxymethyl piperidine moiety. This unique structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds, particularly in the development of kinase inhibitors and other targeted therapies. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate complex fluorinated heterocycles into their molecular designs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and tool compounds to study enzyme function and biological pathways.
• Material Science Precursor: Potential building block for advanced polymers and liquid crystals, where the polar nitrile and hydroxyl groups can influence material properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	3-Fluoro-4-[4-(Hydroxymethyl)Piperidin-1-Yl]Benzonitrile
CAS No.	1157060-75-7
Molecular Formula	C13H15FN2O
Molecular Weight	234.27 g/mol
Synonyms	1-(4-Cyano-2-fluorophenyl)-4-piperidinemethanol; 4-(4-(Hydroxymethyl)piperidin-1-yl)-3-fluorobenzonitrile; 3-Fluoro-4-(4-(hydroxymethyl)piperidin-1-yl)benzonitrile; 1157060-75-7; 3-Fluoro-4-[4-(hydroxymethyl)-1-piperidinyl]benzonitrile; Benzonitrile, 3-fluoro-4-[4-(hydroxymethyl)-1-piperidinyl]-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-[4-(Hydroxymethyl)Piperidin-1-Yl]Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.