Description

4-Amino-5-Nitro-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both amino and nitro substituents on a benzonitrile core with a trifluoromethyl group. This unique structure makes it a critical building block for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Utilized in the production of advanced colorants and photographic chemicals due to its nitro-amino substitution pattern.
• Cross-Coupling Reactions: The amino group allows for further functionalization, making it a versatile substrate for palladium-catalyzed and other metal-mediated coupling reactions.

Basic Information

Product Name	4-Amino-5-Nitro-2-(Trifluoromethyl)Benzonitrile
CAS No.	1155800-54-6
Molecular Formula	C8H4F3N3O2
Molecular Weight	231.14 g/mol
Synonyms	2-(Trifluoromethyl)-4-amino-5-nitrobenzonitrile; 4-Amino-5-nitro-2-(trifluoromethyl)benzonitrile; 5-Nitro-4-amino-2-trifluoromethylbenzonitrile; Benzonitrile, 4-amino-5-nitro-2-(trifluoromethyl)-; 1155800-54-6; 4-Amino-5-nitro-alpha,alpha,α-trifluoro-o-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Nitro-2-(Trifluoromethyl)Benzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if possible and opened only in a controlled, dry environment.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.