Description

cis-3-Fluorocyclopentan-1-Amine is a versatile chiral building block featuring a fluorinated cyclopentane backbone, offering unique steric and electronic properties for advanced molecular design. This compound is critical for medicinal chemistry and agrochemical research, where the introduction of fluorine atoms and specific stereochemistry is used to modulate the bioactivity, metabolic stability, and physicochemical profile of target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced materials with tailored properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorination on molecular conformation and reactivity.

Basic Information

Product Name	cis-3-Fluorocyclopentan-1-Amine
CAS No.	1154870-57-1
Molecular Formula	C5H10FN
Molecular Weight	103.14 g/mol
Synonyms	cis-3-Fluorocyclopentylamine; (1R,3S)-3-Fluorocyclopentanamine; (1S,3R)-3-Fluorocyclopentanamine; 3-Fluorocyclopentan-1-amine (cis); 3-Fluoro-cis-cyclopentylamine; 1-Amino-3-fluorocyclopentane (cis); FCYPA; 1154870-57-1
EINECS	Contact for details

Quality Control

Our cis-3-Fluorocyclopentan-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and consistent enantiomeric excess. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for assay, chiral purity, identity confirmation, and impurity profiles. Our quality standards are designed to meet the rigorous demands of cGMP and ISO-guided production environments for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis isomer)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.