Description

(2-Cyano-3-Fluoro-Phenyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters for its role as a critical building block in modern medicinal chemistry, enabling the introduction of specific functional groups essential for drug activity and selectivity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries developing new therapeutic agents and crop protection products. The compound is supplied to meet the stringent quality and consistency requirements of global GMP and ISO supply chains.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its fluorinated and cyano-substituted aromatic structure.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) in lead optimization programs.
• Process Chemistry: Employed in the scale-up and commercial manufacturing of APIs requiring this specific carbamate-protected aniline derivative.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	(2-Cyano-3-Fluoro-Phenyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1153762-99-2
Molecular Formula	C12H13FN2O2
Molecular Weight	236.25 g/mol
Synonyms	tert-Butyl (2-cyano-3-fluorophenyl)carbamate; N-Boc-2-cyano-3-fluoroaniline; 2-Fluoro-6-((tert-butoxycarbonyl)amino)benzonitrile; 3-Fluoro-2-((tert-butoxycarbonyl)amino)benzonitrile; Boc-2-Cyano-3-fluoroaniline; N-(tert-Butoxycarbonyl)-2-cyano-3-fluoroaniline; (3-Fluoro-2-cyanophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (2-Cyano-3-Fluoro-Phenyl)-Carbamic Acid tert-Butyl Ester is manufactured under a strict quality management system. Every batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.