Description

4-(4-Chlorophenoxy)-3-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both a chlorophenoxy ether linkage and a fluorine substituent, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorinated aromatic core contributes to enhanced biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials due to its electron-withdrawing nitrile group.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl and heteroaryl systems.
• Chemical Research: Utilized in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	4-(4-Chlorophenoxy)-3-Fluorobenzonitrile
CAS No.	1153105-44-2
Molecular Formula	C13H7ClFNO
Molecular Weight	247.65 g/mol
Synonyms	3-Fluoro-4-(4-chlorophenoxy)benzonitrile; 4-(p-Chlorophenoxy)-3-fluorobenzonitrile; Benzonitrile, 4-(4-chlorophenoxy)-3-fluoro-; 1153105-44-2
EINECS	Contact for details

Quality Control

Our production of 4-(4-Chlorophenoxy)-3-Fluorobenzonitrile adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide detailed Certificates of Analysis (COA) with each shipment to ensure full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.