Description

4-Amino-3-Chloro-5-Fluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine substituents for enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, dyes, and polymers with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Amino-3-Chloro-5-Fluorobenzonitrile
CAS No.	1147558-43-7
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	3-Chloro-5-fluoro-4-aminobenzonitrile; 4-Amino-3-chloro-5-fluorobenzene carbonitrile; 2-Chloro-6-fluoro-3-aminobenzonitrile; Benzonitrile, 4-amino-3-chloro-5-fluoro-; 3-Amino-2-chloro-5-fluorobenzonitrile; 4-Cyano-2-chloro-6-fluoroaniline; 2-Chloro-6-fluoro-3-cyanoaniline
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-Chloro-5-Fluorobenzonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. Our standard quality commitment includes comprehensive purity analysis and impurity profiling. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.