Description

3-Fluoro-4-Methyl-5-Nitrobenzonitrile is a high-purity, multi-functional aromatic nitrile building block. This compound is valued for its unique molecular architecture, which combines electron-withdrawing nitro and nitrile groups with a fluorine substituent, making it an essential intermediate in advanced synthetic chemistry. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom and nitrile group contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the nitro and nitrile groups are integral to the chromophore structure.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl and heteroaryl structures.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry within university and CRO laboratories.

Basic Information

Product Name	3-Fluoro-4-Methyl-5-Nitrobenzonitrile
CAS No.	1146290-07-4
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	5-Nitro-3-fluoro-4-methylbenzonitrile; 4-Methyl-3-fluoro-5-nitrobenzonitrile; Benzonitrile, 3-fluoro-4-methyl-5-nitro-; 3-Fluoro-4-methyl-5-nitrobenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methyl-5-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with full batch traceability are provided to guarantee supply reliability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.