Description

Methyl 4,6-Bis(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is critical for researchers and developers seeking to incorporate the unique physicochemical properties of the trifluoromethyl group into novel molecular architectures. It is primarily utilized in the pharmaceutical and agrochemical industries for the research and development of new active ingredients, where its structural motif can enhance metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and antiviral agent discovery.
• Agrochemical Research: Used as a building block for creating new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Serves as a precursor for the synthesis of specialty chemicals and functional materials, including organic electronic components.
• Chemical Biology: Employed in the design and synthesis of molecular probes and bio-active compounds for target identification and validation studies.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex fluorinated molecules.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploration of new chemical space in academic and industrial R&D laboratories.

Basic Information

Product Name	Methyl 4,6-Bis(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate
CAS No.	1146081-29-9
Molecular Formula	C12H6F6N2O2
Molecular Weight	324.18 g/mol
Synonyms	Methyl 4,6-bis(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4,6-bis(trifluoromethyl)-, methyl ester; 4,6-Bis(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester; Methyl 4,6-di(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1146081-29-9
EINECS	Contact for details

Quality Control

Our Methyl 4,6-Bis(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.