Description

1,3-Difluoro-2-Iodo-4-Nitrobenzene is a highly functionalized aromatic building block of significant interest in advanced organic synthesis. Its unique combination of halogen substituents (fluoro and iodo) and a nitro group makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, nucleophilic aromatic substitution, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and iodinated aromatic rings.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and pesticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic materials, such as liquid crystals, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Heck couplings) to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution (SNAr): The activated fluorine atoms, especially ortho to the nitro group, are susceptible to displacement by various nucleophiles, enabling diverse functionalization.
• Chemical Biology & Diagnostics: Can be used to create probes, tags, or radiolabeled compounds (using iodine-125 or iodine-131) for imaging and biochemical studies.

Basic Information

Product Name	1,3-Difluoro-2-Iodo-4-Nitrobenzene
CAS No.	1145881-54-4
Molecular Formula	C6H2F2INO2
Molecular Weight	284.99 g/mol
Synonyms	2-Iodo-1,3-difluoro-4-nitrobenzene; 1,3-Difluoro-2-iodo-4-nitrobenzene; 4-Nitro-1,3-difluoro-2-iodobenzene; Benzene, 1,3-difluoro-2-iodo-4-nitro-; 2,4-Difluoro-1-iodo-5-nitrobenzene (alternative numbering); DFINB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-2-Iodo-4-Nitrobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.