Description

4-Aminomethyl-3-Trifluoromethyl-Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both an aminomethyl and a trifluoromethyl substituent. This unique molecular structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for its ability to enhance metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Fluorine Chemistry Studies: A valuable compound for research into the effects of fluorine substitution on chemical reactivity and physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-Aminomethyl-3-Trifluoromethyl-Benzonitrile
CAS No.	1141894-75-8
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	3-(Trifluoromethyl)-4-(aminomethyl)benzonitrile; 4-(Aminomethyl)-3-(trifluoromethyl)benzonitrile; 4-Cyano-2-(trifluoromethyl)benzylamine; 2-(Trifluoromethyl)-4-cyanobenzylamine; Benzonitrile, 4-(aminomethyl)-3-(trifluoromethyl)-; 1141894-75-8; 4-Aminomethyl-α,α,α-trifluoro-m-toluonitrile
EINECS	Contact for details

Quality Control

Our 4-Aminomethyl-3-Trifluoromethyl-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers' regulatory filings and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.