Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-Fluoro-2-Hydroxymethylpyrrolidine is a high-value, chiral fluorinated pyrrolidine derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex, biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system, oncology, and infectious diseases.
• Protease Inhibitor Synthesis: Used in the construction of fluorinated peptidomimetics and inhibitors for enzymes like HCV NS3/4A protease.
• Chiral Auxiliary & Ligand Precursor: The defined stereochemistry makes it valuable for developing chiral catalysts, auxiliaries, and ligands for asymmetric synthesis.
• Agrochemical Research: Serves as a building block for novel fluorinated pesticides and herbicides, leveraging the fluorine atom's ability to modulate bioavailability and stability.
• Fluorine Chemistry & SAR Studies: Integral for structure-activity relationship (SAR) studies where the introduction of fluorine is used to optimize metabolic stability, lipophilicity, and binding affinity.
• Peptide & Conjugate Chemistry: The hydroxymethyl and Boc-protected amine functionalities allow for further derivatization and incorporation into peptide backbones or bioconjugates.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-Fluoro-2-Hydroxymethylpyrrolidine
CAS No.	1138324-48-7
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	1-Boc-4-fluoro-2-hydroxymethylpyrrolidine (2S,4R); (2S,4R)-1-Boc-4-fluoro-2-(hydroxymethyl)pyrrolidine; (2S,4R)-4-Fluoro-2-(hydroxymethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; (2S,4R)-N-Boc-4-fluoro-2-hydroxymethylpyrrolidine; 1-N-Boc-trans-4-fluoro-L-prolinol; Boc-4-fluoro-2-hydroxymethylpyrrolidine; (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-(hydroxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-(tert-Butoxycarbonyl)-4-Fluoro-2-Hydroxymethylpyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and cGMP starting material applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support our clients with full traceability and regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.