Description

2-Fluoro-4-Hydroxy-5-Nitro-Benzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring orthogonal reactive sites (fluoro, hydroxy, nitro, and nitrile groups), makes it a versatile precursor for constructing complex heterocycles and functionalized intermediates. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and antibacterial research.
• Agrochemical Development: Used in the creation of novel herbicides and pesticides, leveraging the bioactivity of the nitro and fluorine substituents.
• Ligand and Catalyst Synthesis: Serves as a precursor for chelating ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: The nitro and hydroxy groups make it suitable for synthesizing complex colorants.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for C-C and C-N bond formation.

Basic Information

Product Name	2-Fluoro-4-Hydroxy-5-Nitro-Benzonitrile
CAS No.	1134198-38-1
Molecular Formula	C7H3FN2O3
Molecular Weight	182.11 g/mol
Synonyms	5-Nitro-2-fluoro-4-hydroxybenzonitrile; 4-Hydroxy-5-nitro-2-fluorobenzonitrile; 2-Fluoro-4-hydroxy-5-nitrobenzonitrile; Benzonitrile, 2-fluoro-4-hydroxy-5-nitro-; 1134198-38-1; 2-Fluoro-4-hydroxy-5-nitro-benzonitrile; 2-Fluoro-4-hydroxy-5-nitrobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxy-5-Nitro-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.