Description

4-Amino-5-Hydroxy-2-(Trifluoromethyl)Benzonitrile is a high-purity, multi-functional aromatic nitrile building block distinguished by its trifluoromethyl and amino-hydroxy substitution pattern. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorine-containing motifs for enhanced potency and bioavailability.
• Agrochemical Synthesis: Serves as a crucial building block in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials where its specific substitution pattern can influence material properties.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Dye & Pigment Intermediate: Functions as a precursor in the synthesis of specialized dyes and pigments, particularly azo dyes and complex colorants.
• Cross-Coupling Reactions: The nitrile and halogen (if present) functionalities make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.

Basic Information

Product Name	4-Amino-5-Hydroxy-2-(Trifluoromethyl)Benzonitrile
CAS No.	1131623-15-8
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	2-Amino-3-hydroxy-6-(trifluoromethyl)benzonitrile; 2-Cyano-6-(trifluoromethyl)-3-aminophenol; 3-Amino-4-hydroxy-2-(trifluoromethyl)benzonitrile; 4-Amino-5-hydroxy-2-(trifluoromethyl)phenyl cyanide; 5-Amino-4-hydroxy-2-(trifluoromethyl)benzonitrile; Benzonitrile, 4-amino-5-hydroxy-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-4-amino-5-hydroxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Hydroxy-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.