Description

Letrozole is a potent, selective, and non-steroidal aromatase inhibitor of the third generation. This compound is critical for the targeted inhibition of estrogen biosynthesis, offering a high degree of specificity. It is an essential active pharmaceutical ingredient (API) and a key reference standard for research and development. Primary industrial users include pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on oncology and endocrinology.

Application

• Pharmaceutical API: Manufacture of finished dosage forms for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
• Reference Standard: Used in quality control laboratories for the identification and assay of Letrozole in raw materials and finished products via HPLC, GC, or spectroscopic methods.
• Research & Development: Serves as a critical biochemical tool in preclinical studies investigating aromatase inhibition, estrogen-dependent pathways, and cancer biology.
• Analytical Testing: Employed as a certified standard for method development, validation, and regulatory compliance testing (e.g., USP, EP monographs).
• Formulation Development: Used in the development of novel drug delivery systems, including tablets and other solid oral dosage forms.

Basic Information

Product Name	Letrozole
CAS No.	112809-51-5
Molecular Formula	C17H11N5
Molecular Weight	285.31 g/mol
Synonyms	4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile; CGS 20267; Femara®; LTZ; NSC 719345
EINECS	Contact for details

Quality Control

Our Letrozole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with major pharmacopeial standards (USP/EP). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with your specified requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.