Description

6α-Methyl Prednisolone 21-Sulfate Ester is a chemically modified derivative of the potent corticosteroid prednisolone, designed for enhanced solubility and targeted delivery. This sulfate ester prodrug is of significant interest in advanced pharmaceutical research and development, particularly for creating novel therapeutic formulations. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical industry focused on anti-inflammatory, immunosuppressive, and oncological applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel corticosteroid-based drugs with modified pharmacokinetic profiles.
• Prodrug Development: Used in research to develop water-soluble prodrugs of methylprednisolone for improved bioavailability and controlled release.
• Anti-inflammatory Research: Serves as a model compound in studies investigating new delivery mechanisms for potent anti-inflammatory agents.
• Metabolite Studies: Employed as a reference standard in analytical laboratories for the identification and quantification of steroid metabolites.
• Bioconjugation: Acts as a starting material for creating steroid-protein conjugates used in immunoassays and diagnostic applications.
• Formulation Science: Investigated for use in advanced drug delivery systems, including liposomal and nanoparticle formulations.

Basic Information

Product Name	6α-Methyl Prednisolone 21-Sulfate Ester
CAS No.	1127921-80-5
Molecular Formula	C22H30O8S
Molecular Weight	454.54 g/mol
Synonyms	6α-Methylprednisolone 21-sulfate; 6α-Methylprednisolone 21-(hydrogen sulfate); 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-(hydrogen sulfate); Methylprednisolone 21-sulfate; 6α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-sulfate; Prednisolone, 6α-methyl-, 21-(hydrogen sulfate); 6α-Methylprednisolone hydrogen sulfate ester
EINECS	Contact for details

Quality Control

Our 6α-Methyl Prednisolone 21-Sulfate Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for related substances and residual solvents. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.