Description

Benzonitrile, 4-Bromo-2-Chloro-5-Fluoro- is a high-purity, multi-halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its precise molecular architecture, featuring bromo, chloro, and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a versatile precursor in the development of new herbicides, fungicides, and insecticides, where the halogen pattern can influence bioactivity and environmental stability.
• Ligand and Catalyst Development: Used to prepare specialized ligands for transition metal catalysis and organocatalysts, enabling new synthetic methodologies.
• Material Science Precursor: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitrile group and halogen handles.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Benzonitrile, 4-Bromo-2-Chloro-5-Fluoro-
CAS No.	1126779-33-6
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	4-Bromo-2-chloro-5-fluorobenzonitrile; 2-Chloro-5-fluoro-4-bromobenzonitrile; 5-Fluoro-4-bromo-2-chlorobenzonitrile; Benzonitrile, 4-bromo-2-chloro-5-fluoro-; 4-Bromo-2-chloro-5-fluorobenzocarbonitrile; (4-Bromo-2-chloro-5-fluorophenyl)carbonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Bromo-2-Chloro-5-Fluoro- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients with rigorous analytical validation using techniques such as HPLC, GC, NMR, and MS to meet the exacting standards of pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.