Description

4-Chloro-2-Fluoro-5-Methylbenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chloro, fluoro, and methyl substituents on a benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and nitrile groups contribute to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing specialized aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer Chemistry: Employed in the synthesis of monomers and functional polymers, where its aromatic structure and substituents can modify polymer properties.
• General Organic Synthesis: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling diverse molecular architectures.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Details
Product Name	4-Chloro-2-Fluoro-5-Methylbenzonitrile
CAS No.	1126424-34-7
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	4-Chloro-2-fluoro-5-methylbenzonitrile; 2-Fluoro-4-chloro-5-methylbenzonitrile; 5-Methyl-2-fluoro-4-chlorobenzonitrile; Benzonitrile, 4-chloro-2-fluoro-5-methyl-; 4-Chloro-2-fluoro-5-methyl-benzonitrile; 1126424-34-7 (CAS); 4-Chloro-2-fluoro-5-methyl benzyl cyanide (common name variant)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Methylbenzonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.