Description

3,4-Difluoro-5-Nitrobenzonitrile is a high-purity, multi-functional aromatic nitrile building block used in advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective chemical transformations in the creation of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro and nitro groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl and conjugated systems.
• Nucleophilic Aromatic Substitution: The nitro and cyano groups activate the fluorines for efficient substitution, making it a valuable scaffold for introducing diverse functionalities.

Basic Information

Item	Detail
Product Name	3,4-Difluoro-5-Nitrobenzonitrile
CAS No.	1119454-07-7
Molecular Formula	C7H2F2N2O2
Molecular Weight	184.10 g/mol
Synonyms	5-Nitro-3,4-difluorobenzonitrile; 3,4-Difluoro-5-nitrobenzenecarbonitrile; Benzonitrile, 3,4-difluoro-5-nitro-; 1119454-07-7 (CAS); 3,4-Difluoro-5-nitro-benzonitrile
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity building blocks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.