Description

2-Chloro-3-Fluoro-4-Iodobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the halogen atoms can contribute to biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution, enabling rapid diversification of chemical libraries.
• Life Science Reagents: Utilized in the preparation of biochemical probes, fluorescent tags, and other diagnostic tools for research and development.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-Iodobenzonitrile
CAS No.	1114547-55-5
Molecular Formula	C7H2ClFIN
Molecular Weight	281.45 g/mol
Synonyms	4-Iodo-2-chloro-3-fluorobenzonitrile; 2-Chloro-3-fluoro-4-iodobenzonitrile; Benzonitrile, 2-chloro-3-fluoro-4-iodo-; 3-Fluoro-2-chloro-4-iodobenzonitrile; 4-Cyano-2-chloro-3-fluoro-1-iodobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-Iodobenzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.