Description

4-Bromo-2-Fluoro-3-Methylbenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures with precise electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Serves as a versatile building block for developing new herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for bioactivity and metabolic stability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and in the synthesis of functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Advanced Material Science: A precursor for liquid crystals, organic semiconductors, and polymers requiring specific halogenated aromatic units.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	4-Bromo-2-Fluoro-3-Methylbenzonitrile
CAS No.	1114546-30-3
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Bromo-2-fluoro-3-methylbenzonitrile; 2-Fluoro-3-methyl-4-bromobenzonitrile; 3-Methyl-4-bromo-2-fluorobenzonitrile; Benzonitrile, 4-bromo-2-fluoro-3-methyl-; 1114546-30-3; 4-Bromo-2-fluoro-3-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Fluoro-3-Methylbenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity (by IR and NMR), and impurity profile. Our quality commitment supports compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.