Description

Benzonitrile, 5-Bromo-2-Fluoro-3-Methyl- is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique molecular structure, which combines bromine, fluorine, and a nitrile group on a methyl-substituted benzene ring, enabling precise chemical modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients. The CAS number for this product is 1110502-49-2.

Application

This versatile intermediate is engineered for advanced synthetic applications, serving as a critical precursor in several high-value sectors.

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the reactivity of its halogen substituents.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling reagent in the design of chemical probes and activity-based protein profiling (ABPP) studies.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings due to the presence of bromine.

Basic Information

Item	Details
Product Name	Benzonitrile, 5-Bromo-2-Fluoro-3-Methyl-
CAS No.	1110502-49-2
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	5-Bromo-2-fluoro-3-methylbenzonitrile; 3-Methyl-5-bromo-2-fluorobenzonitrile; 2-Fluoro-3-methyl-5-bromobenzonitrile; 5-Bromo-2-fluoro-m-tolunitrile; 2-Fluoro-5-bromo-3-methylbenzonitrile; Benzonitrile, 5-bromo-2-fluoro-3-methyl-; 1110502-49-2
EINECS	Contact for details

Quality Control

Our Benzonitrile, 5-Bromo-2-Fluoro-3-Methyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity building blocks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.