Description

5-(3,5-Difluorobenzyl)-2-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique difluorobenzyl and fluorobenzonitrile structure makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano-group transformations to introduce complex fluorinated aromatic systems.
• Chemical Research & Development: Utilized in academic and industrial R&D settings for exploring new synthetic methodologies and material properties.

Basic Information

Product Name	5-(3,5-Difluorobenzyl)-2-Fluorobenzonitrile
CAS No.	1108745-25-0
Molecular Formula	C14H8F3N
Molecular Weight	247.22 g/mol
Synonyms	2-Fluoro-5-[(3,5-difluorophenyl)methyl]benzonitrile; 5-[(3,5-Difluorophenyl)methyl]-2-fluorobenzonitrile; 2-Fluoro-5-(3,5-difluorobenzyl)benzonitrile; Benzonitrile, 5-[(3,5-difluorophenyl)methyl]-2-fluoro-; 1108745-25-0; 5-(3,5-Difluorobenzyl)-2-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 5-(3,5-Difluorobenzyl)-2-Fluorobenzonitrile is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.